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Pregnyl®
Substance: HCG-gonadotropin
Delivery: 3vial's (1500/2500/5000)IU
Manufacturer: Greece, Organon

Chorionic
gonadotropin is a hormone found in the female body during the early
months of pregnancy (it is produced in the placenta). It is in fact
the pregnancy indicator looked at by the over the counter pregnancy
test kits, as due to its origin it is not found in the body at any other
time. Blood levels of this hormone will become noticeable as early as
seven days after ovulation. The level will rise evenly, reaching a peak
at approximately two to three months into gestation. After this point,
the hormone level will drop gradually until the point of birth. As a
prescription drug, HCG offers us some interesting benefits. In the United
States, we have the two popular brands, Pregnyl, made by Organon, and
Lepori, made by Farma-
Lepori.
These
are FDA approved for the treatment of undescended testicles in young
boys, hypogonadism (underproduction of testosterone) and as a fertility
drug used to aid in inducing ovulation in women. When prepared as a
medical item, this hormone comes from a human origin. Although there
is often a fear of biological origin products, there is little research
to be found regarding pathogen or sterility problems with HCG. The problems
seen with human origin growth hormone are certainly not to be repeated
with HCG, as this compound is obtained in a much different way.

While HCG offers the female no performance
enhancing ability, it does prove very useful to the male steroid user.
The obvious use of course being to stimulate the production of endogenous
testosterone. The activity of HCG in the male body is due to its ability
to mimic LH (luteinizing hormone), a pituitary hormone that stimulates
the Leydig's cells in the testes to manufacture testosterone. Restoring
endogenous testosterone production is a special concern at the end of
each steroid cycle, a time when a subnormal androgen level (due to steroid
induced suppression) could be very costly. The main concern is the action
of cortisol, which in many ways is balanced out by the effect of androgens.
Cortisol sends the opposite message to the muscles than testosterone,
or to breakdown protein in the cell. Left unchecked (by an extremely
low testosterone level) in the body, cortisol can quickly strip much
of your new muscle mass away.

The
main focus with HCG is to restore the normal ability of the testes to
respond to endogenous luteinizing hormone. After a long period of inactivity,
this ability may have been seriously reduced. In such a state testosterone
levels may not reach a normal point, even though the release of endogenous
LH has been resumed. Many who have suffered severe testicular shrinkage
may be able to relate, as it is often some time before normal testicle
size and feelings of virility are restored if ancillary drugs had not
been used. The excessive stimulation brought forth by administration
of HCG can likewise cause the testicles to rapidly return to their normal
size and level of activity. We are not simply looking for it to fix
the problem however, as the resulting high testosterone level can itself
trigger negative feedback inhibition at the hypothalamus. Estrogen production
is also heightened with the use of HCG, due to its ability to increase
aromatase activity in the Leydig's cells. This is due to the main action
of HCG, namely the increase of cycIicAMP (a secondary messenger that
regulates cellular activity). When stimulated by HCG, the ability of
the testes to aromatize androgens could potentially be heightened several
times greater than normal. This also may inhibit testosterone production,
so we therefore use HCG only as a quick shock to the testes.

The
usual protocol is to inject 1500-3000 I.U. every 4'" or 5t"
day, for a duration usually no longer than 2 or 3 weeks. If used for
too long or at too high a dose, the drug may actually function to desensitize
the Leydig's cells to luteinizing hormone, further hindering a return
to homeostasis. Timing the initial dose is also very crucial. If your
were coming off a cycle of Sustanon for example, testosterone levels
in your blood will likely stay elevated for at least 3 to 4 weeks after
your last injection. Taking HCG on the day of your last shot would therefore
be useless. Instead one would want to calculate the last week in which
androgen levels are likely to be above normal, and begin ancillary drug
therapy at this point. In this case HCG would be started around the
third or fourth week. Likewise, after ending a cycle of Dianabol (an
oral) your blood levels will be sub normal after the third day. Here
you may want to begin HCG therapy a few days before your last intake
of tablets, giving it a few days to take effect. One would also want
to give some thought to the level of suppression that the cycle might
have brought about. After an 8 week cycle of Androlic50® for example,
1500-2500 I.U. would likely be a sufficient initial dosage. The lower
amount of hormonal suppression one associates with this drug would probably
not require much more. On the other hand, 750-1000mg of Sustanon250®
per week might incline the user to inject a much larger HCG dose, perhaps
as much as 5000 I.U. for the opening application. It may thereafter
also be a good idea to reduce the dosage on subsequent shots, so as
to step down the intake of HCG during the two or three weeks of intake.

As
discussed above, HCG acts only to mimic the action of LH. It is likewise
not the perfect hormone to combat testosterone suppression, and for
this reason it is used most often in conjunction with estrogen antagonists
such as Clomid® or Tamoxifen® . These drugs have a different
effect on the regulating system, namely inhibiting estrogen-induced
suppression at the hypothalamus. This of course also helps to restore
the release of testosterone, although through a much different mechanism
than HCG. A combination of both drugs appears to be very synergistic,
HCG providing an immediate effect on the testes (shocking them out of
inactivity) while the antiestrogen helps later to block inhibition on
the hypothalamus and resume the normal release of gonadotropins from
the pituitary. The typical procedure involves giving the Clomid®,
Tamoxifen® dose from the start with HCG, but continuing it alone
for a few weeks once HCG has been discontinued. This practice should
effectively raise testosterone levels, which will hopefully remain stable
once Clomid®, Tamoxifen® have been discontinued. While unfortunately
there is no way to retain all of the muscle gains produced by anabolic
steroids, using ancillaries to restore a balanced hormonal state is
the best way to minimize the loss felt with ending a cycle.

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